Arbaclofen Extended-Release for the Treatment of Spasticity in Multiple Sclerosis: An Open-Label Safety Study (Study OS440-3005)
Background: Despite pharmacologic therapy, people with multiple sclerosis (MS) often experience spasticity, which can worsen with longer...
Arbaclofen Extended-Release for Spasticity in Multiple Sclerosis: Responder Analysis of a Phase 3 Randomized, Placebo-Controlled Clinical Study OS440-3004
Background: Arbaclofen is the active R-enantiomer of racemic baclofen. Arbaclofen extended-release (ER) tablets have demonstrated efficacy...
Validation and Minimal Detectable Change of the Walking While Talking Test As a Measure of Dual-Task Performance in Ambulatory Individuals with Multiple Sclerosis
Background: Multiple Sclerosis (MS) is a progressive neurodegenerative disease associated with demyelination of the central nervous system...
Attitude and Perception of Multiple Sclerosis Patients Toward Exercise
Background: Contrary to the common belief that physical training for Multiple Sclerosis (MS) patients might exacerbate fatigue and provoke...
A Scoping Review of Task-Oriented Exercise Effects on Motor Function in People with Multiple Sclerosis
Background: Exercise improves cardiorespiratory and musculoskeletal fitness for people with multiple sclerosis (MS). Recent work suggests...
Contradictory Roles of Exercise Participation: A Qualitative Synthesis
Background: Exercise is becoming increasingly medicalized among populations experiencing disability such as those with multiple sclerosis...
Coping Moderates the Association between Symptoms and Functional and Affective Outcomes in the Daily Lives of Individuals with Multiple Sclerosis
Background: Pain and fatigue are highly prevalent in multiple sclerosis (MS) and are associated with adverse outcomes spanning the...
Is Depression Associated with Volume and Pattern of Sedentary Behavior in Persons with Multiple Sclerosis?
Background: Depression is highly prevalent and influences physical function and mobility disability in persons with MS. There are data...