Abstracts

Poster-Non-imaging Biomarkers

Concentration of Evobrutinib, a Bruton’s Tyrosine Kinase Inhibitor, in Cerebrospinal Fluid during Treatment of Patients with Relapsing Multiple Sclerosis in a Phase 2 Study

Background: Evobrutinib, a highly selective Bruton’s tyrosine kinase (BTK) inhibitor, demonstrated a low annualized relapse rate (75mg...

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Poster-Non-imaging Biomarkers

The Effect of Evobrutinib, a Bruton’s Tyrosine Kinase Inhibitor, on Blood Neurofilament Light Chain Levels in Relapsing Multiple Sclerosis

Background: Evobrutinib is a highly selective Bruton’s tyrosine kinase inhibitor targeting B cells and myeloid cells. A phase 2 randomized...

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Poster-Neurophysiology; Neuropsychology and Neuropsychiatry

Validation of Paced Auditory Serial Addition Test (PASAT) Regression Normative Data for Performance and Cognitive Fatigability in Multiple Sclerosis

Background: Cognitive fatigability (CF) can be defined as an objective decline in performance that occurs over time during sustained...

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Poster-Neurophysiology; Neuropsychology and Neuropsychiatry

Evaluation of Apathy in Multiple Sclerosis

Background: Features of apathy include lack of initiation, lack of interest, reduced spontaneity, indifference, and reduced self-awareness....

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Poster-Non-imaging Biomarkers

Validating the Clinical Usefulness of the Timed 25-Foot Walk in MS in Routine Clinical Practice

Background: Multiple Sclerosis (MS) is a chronic and degenerative autoimmune disease of the central nervous system which can cause...

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Poster-Methods of Care

Development and Implementation of a Psychoeducational Model for a Pediatric MS Clinic Transition Program

Background: Multiple Sclerosis (MS) is less commonly diagnosed in children than in adults with an estimated prevalence of 5,000 in the US...

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Poster-Neuroimmunology and disease models

RGC-32 Contributes to Reactive Astrocytosis in Experimental Autoimmune Encephalomyelitis By Maintaining a Mature Phenotype

Background: Astrocytes are increasingly recognized as critical contributors to the pathogenesis of multiple sclerosis and experimental...

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Poster-Neuroimmunology and disease models

Mucosal Associated Invariant T (MAIT) Cells Show Defective Activation in People with Multiple Sclerosis

Background: mucosal associated invariant T (MAIT) cells are innate-like T cells expressing an invariant TCR ? chain with a limited number...

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Poster-Neurophysiology; Neuropsychology and Neuropsychiatry

Stability of the Gut Microbiota in Persons with Pediatric-Onset Multiple Sclerosis and Related Demyelinating Diseases

Background: Little is known about the stability of the gut microbiota in multiple sclerosis (MS) over time. Objectives: To determine if the...

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