neuroimmunology and disease models

Background: Astrocytes are increasingly recognized as critical contributors to the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Our research has shown that Response...

Background: The association between multiple sclerosis (MS) and Epstein-Barr virus (EBV) is well known. Previously, it’s been shown that antibodies to EBV protein BFRF3 cross-react...

Background: Few population-level sex-based risk estimates of specific infections exist for US patients with multiple sclerosis (MS). Objectives: To quantify the sex-based relative risk (RR)...

Background: Optic neuritis (ON) is an immune-mediated optic neuropathy associated with multiple immune-mediated neurological conditions. Objectives: To identify clinical, and diagnostic features of initial episodes...

Background: mucosal associated invariant T (MAIT) cells are innate-like T cells expressing an invariant TCR ? chain with a limited number of ?-chains. MAIT cells...

Background: Polymorphisms within the IL2RA gene (CD25) is a risk factor for multiple sclerosis (MS), raising the possibility that IL2 promotes pathogenesis. Though IL2 is...