Sessions 1 and 2 of Fundamentals offers a multidisciplinary approach in the diagnosis and management of multiple sclerosis (MS). The history of MS will offer participants an insight into the disease and the changes that have led to improved approaches to management. A comprehensive overview of MS will be presented to include epidemiology, immunology, pathophysiology, natural history, and clinical course. Presentations will include whats involved in making the diagnosis of MS, disease mimics and use of paraclinical tools. The challenges in diagnosing and managing primary progressive MS will provide attendees an insight into this less common phenotype. Specific populations, including Pediatric MS, and Womens Issues will be discussed. Recent research in the use of marijuana in the MS population will close out Session 2.