Background: Multiple Sclerosis is a chronic autoimmune disease that affects the Central Nervous System, causing destruction of myelin, and it is believed to be caused by a combination of environmental and genetic factors. Objectives: This study aimed to evaluate the influence of conventional physical therapy and the Pilates method in patients with recurrent remitting multiple sclerosis (RRMS) undergoing treatment at Brazilian Association of Multiple Sclerosis (ABEM) on their daily activities, functional skills and quality of life. Methods: We retrospectively analyzed 25 medical records of patients with RRMS submitted to treatment at ABEM, from 2018 to 2019, measured using the Berg Scale (balance), MFIS – Modified Fatigue Impact Scale (fatigue), MRC – Medical Research Council (strength) and MSQOL-54 (quality of life). Results: With the significance level adopted for p <0.05, by the Wilcoxon test, we obtained MFIS: conventional p=0.030 and Pilates p=0.005, BERG: conventional p=0.015 and Pilates p=0, 004, MSQOL-54 (Physical): Conventional p=0.263 and Pilates p=0.009 and MSQOL-54 (Mental): Conventional p=0.807 and Pilates p=0.028. Conclusions: Both fatigue and balance evaluation were improved, but the Pilates method was significantly better. In quality of life, the conventional method showed no significant improvement, while the Pilates method showed both physical and mental improvement.