Background: , Multiple Sclerosis is a chronic neurological disease, characterized by demyelination of neurons in the Central Nervous System that occurs by an immune-mediated response. It can trigger motor, sensory and cognitive symptoms according to its lesional topography. Currently, there are three subtypes named according to their clinical evolution, being remitting-recurring, primarily-progressive, secondarily-progressive.Objectives:, To analyze the effect of telerehabilitation in patients with Multiple Sclerosis during the isolation period of the pandemic of COVID-19.Methods:, This is a retrospective study through the analysis of medical records, with adult individuals affected by Multiple Sclerosis, through the scores of some scales. They are – MFIS (Modified Fatigue Impact Scale), EDSS (Expanded Disability Status Scale) and MSQOL-54 (Multiple Sclerosis Quality Of Life-54).Results:, The Wilcoxon Signed Test Station was applied to verify the differences between the moments of pre and post-intervention. In general, the MFIS scores at the time of pre-intervention are higher than the post-intervention. As for the MSQOL-54 scale, the scores were lower in the pre-intervention period than in the post-intervention period. Spearman’s correlation analysis was applied, verifying the degree of relationship between the variables of the scale results and age, sex and EDSS. The EDSS demonstrated a good relationship with both the MFIS scale and the MSQOL-54.Conclusions: , We show that telerehabilitation performed during the pandemic period has a positive effect on the feeling of fatigue and quality of life of patients with Multiple Sclerosis.