Background: The Multiple Sclerosis Achievement Center (MSAC) conducts day wellness programs to address physical, cognitive and social well-being. Program activities include individualized and group exercise, cognitive stimulation, education, socialization, and community outings. Baseline, one-year and two-year follow-up data previously presented at Consortium of MS Centers meetings. Objectives: To determine, through the use of patient reported outcome (PRO) measures, if members of these wellness programs improve in areas of self-reported disease impact and quality of life over a three year period. Methods: Baseline data was collected through patient reported outcome measures for 110 people with multiple sclerosis (PwMS), who participated in MSAC day wellness programs. Of those 110, two-year data for 86 PwMS was collected in January 2019 and three-year data was completed for 62 PwMS in January 2020. Analysis using t-tests compared data collected at baseline, one, two and three year intervals. Outcome measures include the Multiple Sclerosis Impact Scale (MSIS-29), Multiple Sclerosis Self-Efficacy Scale-10 item (MSSE), Godin Leisure Time Exercise Questionnaire (GTLEQ) and Neuro-QoL (questions from the Anxiety, Depression, Emotion & Behavior, Positive Affect, Cognition, Ability to Participate, and Social Roles sections were used). Outcomes were completed at the MSAC as part of the members weekly program participation. Analysis compared data from the initial analysis to the three-year results. Results: Correlations between reports of Self-Efficacy, Anxiety, Ability to Participate, and Positive Affect were seen with both one and two-year analyses. Analysis from baseline demonstrated statistically significant improvement in Neuro-QoL sections Ability to Participate (p=.02) year two and (p=.004) year three and Social Roles (p=.001) year two and (p=0.004) year three. Other notable changes in three year data include significant changes in MSSE (p=.02) and MSIS (p=.03). NeuroQoL measures of Depression and Emotional Behavioral Dyscontrol were not significant when compared to baseline, but were significant compared to one year scores. Conclusions: Individuals who participate in a weekly, structured day wellness program show significant improvements in quality of life. Some improvements are seen at one year and sustained through a three year period. Other improvements are not realized until two years, but maintained at three years.