Arbaclofen Extended-Release for Spasticity in Multiple Sclerosis: Responder Analysis of a Phase 3 Randomized, Placebo-Controlled Clinical Study OS440-3004
Background: Arbaclofen is the active R-enantiomer of racemic baclofen. Arbaclofen extended-release (ER) tablets have demonstrated efficacy...
Identifying and Characterizing Fatigue in Patients Diagnosed with Multiple Sclerosis on Disease-Modifying Therapies Using Real World Evidence
Background: Fatigue is a common symptom in patients with Multiple Sclerosis (MS). Payor databases represent an important source of real...
Arbaclofen Extended-Release for the Treatment of Spasticity in Multiple Sclerosis: A Randomized, Multi-Center, Placebo-Controlled Clinical Trial (Study OS440-3004)
Background: Arbaclofen, the active R-enantiomer of baclofen, a racemic g-aminobutyric acid-B (GABAB) receptor agonist, has been a mainstay...
Arbaclofen Extended-Release for the Treatment of Spasticity in Multiple Sclerosis: An Open-Label Safety Study (Study OS440-3005)
Background: Despite pharmacologic therapy, people with multiple sclerosis (MS) often experience spasticity, which can worsen with longer...
A Review of Participant Characteristics in Theory-Based Physical Activity Behavior Change Programs in MS: Missing the Greatest Potential for Lifelong Benefits
Background: Physical activity may be beneficial for people with multiple sclerosis (MS), but this population is still physically inactive...
Effect of Ocrelizumab on Antibody Responses to EBV
Background: The association between multiple sclerosis (MS) and Epstein-Barr virus (EBV) is well known. Previously, it’s been shown...
Predicting Stress Levels and Response to a Self-Management Program Using Participant Demographic, Clinical, and Biomarker Data: A Secondary Analysis
Background: Stress management techniques are actively being pursued for multiple sclerosis (MS); the utility of biomarkers for predicting...
Promising Opportunities to Integrate Health and Wellness Coaching into Comprehensive Care Teams for Patients with Multiple Sclerosis
Background: The impact of unhealthy lifestyle behaviors and comorbidities is a rapidly rising focus in treating patients with Multiple...